منابع مشابه
Functional Reconstitution into Liposomes of Purified Human RhCG Ammonia Channel
BACKGROUND Rh glycoproteins (RhAG, RhBG, RhCG) are members of the Amt/Mep/Rh family which facilitate movement of ammonium across plasma membranes. Changes in ammonium transport activity following expression of Rh glycoproteins have been described in different heterologous systems such as yeasts, oocytes and eukaryotic cell lines. However, in these complex systems, a potential contribution of en...
متن کاملRhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels
Rhesus glycoprotein homologs RhAG, RhBG, and RhCG comprise a recently identified branch of the Mep/Amt ammonia transporter family. Animal studies have shown that RhBG and RhCG are present in the kidney distal tubules. Studies in mouse and rat tissue suggest a basolateral localization for RhBG in cells of the distal tubules including the alpha-intercalated cells (alpha-IC), but no localization o...
متن کاملChanges in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis.
The primary mechanism by which the kidneys mediate net acid excretion is through ammonia metabolism. In the current study, we examined whether chronic metabolic acidosis, which increases ammonia metabolism, alters the cell-specific and/or the subcellular expression of the ammonia transporter family member, Rhcg, in the outer medullary collecting duct in the inner stripe (OMCDi). Chronic metabol...
متن کاملCharacterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG.
The erythrocyte Rh-associated glycoprotein (RhAG) was recently found to mediate transport of ammonia/ammonium when expressed in Xenopus laevis oocytes and yeast Saccharomyces cerevisiae. Nonerythroid homologs, RhBG and RhCG, are expressed in the mammalian kidney connecting segment and the collecting duct, major sites of urinary ammonia secretion. This study characterizes the transport propertie...
متن کاملShahram Khademi and Robert M . Stroud Mechanism of Ammonia Gas Conduction
[PDF] [Full Text] [Abstract] , June 1, 2009; 212 (11): 1716-1730. J Exp Biol Dirk Weihrauch, Michael P. Wilkie and Patrick J. Walsh Ammonia and urea transporters in gills of fish and aquatic crustaceans [PDF] [Full Text] [Abstract] 2010; 192 (1): 94-103. J. Bacteriol. David R. Scott, Elizabeth A. Marcus, Yi Wen, Siddarth Singh, Jing Feng and George Sachs Helicobacter pylori , Is Necessary f...
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ژورنال
عنوان ژورنال: Computational Molecular Bioscience
سال: 2020
ISSN: 2165-3445,2165-3453
DOI: 10.4236/cmb.2020.103006